The British Heart Foundation is aiming to raise £50m over the next 10 years with a campaign to mark its 50th anniversary this year.
The Mending Broken Hearts Appeal, which was launched today, is the biggest campaign the charity has undertaken.
The money raised will be used to fund research into regeneration medicine to find a way of repairing or replacing damaged heart muscle.
Events for the appeal will include sponsored bike rides. A compilation CD of love songs from the past 50 years will be released, to be sold at major retailers and online.
Artwork has been created specially for the appeal by renowned contemporary British artists, including Sir Peter Blake and the late Donald Hamilton Fraser. The work will be sold as limited-edition silkscreen prints and on a homeware range.
Fraser had agreed to contribute to the campaign before his death in 1999. His widow subsequently gave permission for a Valentine’s Day card he had painted for her to be turned into a silkscreen print.
A spokeswoman for the BHF said it had taken the charity two years to plan the campaign and that it would be running other campaigns alongside this one over the coming years.