Barnardo's and Dyslexia Action have joined three universities, a college and a public sector consultancy in signing up to pathfinder projects due to begin in September. Microsoft and Unilever are among other supporters vetted by the DfES.
Trust schools will be foundation schools with charitable status.
Barnardo's already works with teenagers in danger of being excluded from schools in Worcestershire. It said the trust school scheme was a natural extension of this.
The charity's midlands director, Sam Monaghan, said it was "too early to make an informed comment about how the partnership is going to work in practice".
Dyslexia Action, which will partner a Plymouth primary school, also declined to elaborate.