Projects that help country-dwellers suffering from stress will get £300,000 from the Government.
National and local charities have until 9 February to submit applications for funding under the fifth Defra Rural Stress Action Plan. A second application window opens after March.
The plan is run by the Rural Stress Information Network, and grants are expected to range from £5,000 to £75,000. Part-funding of the proposals from other sources is encouraged.
The money will be available to groups that work with people who live or work in rural areas, as well as those with debt problems and those at risk of suicide.
Rural affairs Minister Alun Michael said: "The Rural Stress Action Plan has helped many people over the past five years, and this money demonstrates our continued commitment to helping rural communities gain access to the support they need."