The chief executive of Kidney Research UK is to step down in September after nine years in the role.
Charles Kernahan will be replaced by Sandra Currie, who is currently the group director of external affairs and knowledge at the deafblind charity Sense.
A spokesman for the charity said that Kernahan was leaving to pursue "long-term personal and professional goals".
Currie has worked in the voluntary sector for more than 20 years, which included a 15-year spell at Marie Curie Cancer Care.
She joined Sense in 2009 and has responsibility for public policy, advice and research, legal services, communications and voluntary income generation.
Currie said: "It is an enormous privilege to be given the opportunity to lead Kidney Research UK and to continue to develop and then deliver the plans for the future."
"I share Kidney Research UK’s desire to see the lives of all kidney patients improve and I admire the ambitious research programme that aims to achieve that."
Professor Neil Turner, the charity’s chair, is also stepping down after serving his second three-year term. He will be replaced by Professor Tim Goodship, an existing trustee who works for Newcastle University’s Institute of Genetic Medicine.
Goodship said: "My predecessor, Professor Turner, has been an outstanding chair. He and Charles Kernahan can take great pride in the legacy they are passing on. I am looking forward to working with Sandra Currie as the charity seeks to maintain and build on this."The charity had an income of almost £8m in 2011.