Medecins Sans Frontieres, Merlin and Oxfam were among the NGOs to send assistance teams to Iran to help with the aid effort following the massive earthquake around the town of Bam on Boxing Day.
Medical relief charity Merlin has sent staff from Jordan, Iraq and the UK, together with medical supplies such as anti-cholera drugs, antibiotics and blankets.
Chief executive Geoff Prescott said: "Given the scale of devastation, it is crucial that we not only respond quickly, but also that we provide the right type of intervention. Without shelter, water or sanitation, this tragedy could escalate to unimaginable proportions."
MSF has sent teams from London, Brussels and Madrid, and ten tonnes of supplies from Bordeaux.
But the charity warned that, "despite the mass arrival of many aid actors, the organisation of aid remains random, particularly the distribution of non-food materials".
Cafod has given £100,000 to Islamic Relief Worldwide to help with the assistance effort.