Amnesty International is to appoint five senior directors to its London office, each on a salary of around £50,000.
The directors will be responsible for implementing the new broader remit to which the 41-year-old human rights organisation is now committed.
Traditionally, Amnesty has restricted its influence to civil and political campaigns, on issues such as torture and imprisonment without trial. But in a major shift of emphasis it is now working to influence economic, social and cultural issues as well.
Directors are sought for communications and campaigning, resources, international law and organisations, regional planning, policy and evaluation.
Although UK-based, the vacancies are for Amnesty's International Secretariat and have been advertised globally.
Amnesty spokeswoman Liz Willmott said the new mandate will enable it to campaign on issues such as corporate responsibility, racism and education.