The week, which will promote the work of trustees and encourage more people to take up the job, will run from 25 to 31 October.
The commission estimates that half of all charities have a vacancy on their board. There are 800,000 trustees in the UK.
The week is being run in partnership with several organisations that support and recruit trustees, including the National Council for Voluntary Organisations, Charity Trustee Networks, Reach Volunteering, Getting on Board and the Institute of Chartered Accountants in England and Wales.
Dame Suzi Leather, chair of the Charity Commission, said: "During Trustees’ Week we want to celebrate trustees’ huge contribution to society.
"We would also like to raise awareness beyond the charity sector of just what trusteeship is all about.
"Many people have skills and experience that they could bring to being a charity trustee, but our research shows that often people do not know what the role entails."