Arts Council England is taking applications for four funding streams likely to be worth more than £15m.
The Exceptional Awards programme is a general fund that will provide grants for up to 25 one-off arts projects over two years, with a value of between £50,000 and £250,000.
Unlimited II, a programme to support deaf and disabled artists, will initially make a single grant of £1.5m to an organisation that will carry out a programme of mentoring and commissioning from 2013 to 2016. It follows on from a previous programme that ran from 2009 to 2012.
Cultural Destinations, a £3m partnership with VisitEngland, will support cultural organisations that work in tourist destinations and will make grants of between £250,000 and £350,000. It will fund projects to run from March 2014 for a maximum of three years.
Enterprising Libraries is a £1.3m fund – including £600,000 from the Department for Communities and Local Government and £367,000 from the British Library – that will support libraries as hubs for enterprise. Only £450,000 is available to general applicants, in ten grants of up to £45,000.
ACE said it had also streamlined the application process of its Grants for the Arts programme, which gives awards of £1,000 to £100,000 to arts organisations.
Alan Davey, chief executive of Arts Council England, said: "The funds announced today are so important because they can help artists, arts and cultural organisations to demonstrate what arts and culture can really do for this country.
"From supporting deaf and disabled artists to make truly innovative art that challenges the public’s perception of disability, to demonstrating how public libraries can play a huge role in supporting their local economies, the arts are truly transformative."