The winning organisation will receive £10,000, while three runners up will receive £5,000.
London Councils, formerly the Association of London Government, will use the awards to honour projects that improve services to homeless people, prevent homelessness, or remedy the disadvantages that homelessness causes.
Last year’s winner was Look Ahead Housing and Care, a Kensington and Chelsea-based group that provides temporary housing and support for homeless people.
The awards were established in 1998 as a memorial to Andy Ludlow, former director of Housing and Social Services in Haringey.
Applications are open to registered social landlords, housing and social service departments, NHS trusts and voluntary organisations in London. The closing date for entries is 4 June.
The winners will be announced in November.