The Big Lottery Fund has announced the 50 areas where community groups will be able to apply for funding from its new £200m funding stream, Big Local.
The areas, spread across most of England, will each be given at least £1m from the fund.
The BLF will set up an independent charitable trust to give out the money and is looking for a partner organisation to run the trust. Expressions of interest must be submitted to the BLF by 12 August.
The local grants, which will last for 10 years, will be targeted at neighbourhoods that have a history of difficulty in obtaining resources, including BLF funding.
Peter Wanless, chief executive of the BLF, said: "The funding stream will help local people identify their pressing issues and develop the skills and confidence necessary to start changing things in their community for the better.
"The trust will involve people in each of the selected 50 areas to decide on the best way to use the funding."
The BLF will select at least 50 more areas in England over the next 18 months that will be able to apply for funds from the programme.