Jon Barrick is to step down as chief executive of the Stroke Association next May after 12 years in charge.
The charity, which exists to reduce the prevalence of strokes and help people affected by them, is expecting to start the process of finding a new chief executive in late summer or early autumn.
Barrick told Third Sector that he planned to continue to work within the voluntary sector "in ways yet to be determined, but not in a full-time capacity".
The charity’s income in the financial year to 31 March 2014 was £33.5m and its expenditure was £31.9m. In 2009, the equivalent figures were £22.1m and £22.8m.
Barrick said in a statement that he felt the time had come to move on. He said: "I have been very privileged to have been in this exciting and inspiring role for the time that I have, but it is all-consuming and has required me to operate at a high level of intensity over many years. For this reason I have decided that it is now time to let someone else take over and for me to recharge my batteries."