The charity said the change had been decided on because much of the research it carries out can benefit children with other forms of cancer.
The charity, founded in 1988, registered the name Children with Cancer UK with the Charity Commission in 2007. It has already consulted supporters about the change.
Apart from the name change, there will be no alterations to the charity’s logo or other branding.
Caroline Blakely, chief executive of Children with Cancer UK, said: "From small beginnings as a memorial charity more than 23 years ago, we have evolved into a major force in paediatric oncology, helping to drive childhood leukaemia survival rates up to more than 80 per cent.
"As much of the research we fund now and in the future could benefit children with other forms of cancer, we will now lead the fight, not only against childhood leukaemia but also against other forms of childhood cancer."