An alliance of five aid agencies including Oxfam and World Vision has asked 10,000 UK schools and youth clubs to participate in the world's biggest lesson on HIV/Aids on World Aids Day.
The Global Movement for Children invited schools to join 2.7 million children across 44 countries to take part in its Lesson for Life on 1 December.
The lesson, which aims to inform young people about the grave consequences of HIV/Aids around the world, will use methods of discussion, play and drama to teach children about the Aids pandemic.
Lessons will concentrate on how women and girls are affected, explore the difference between HIV and Aids and tell children how they could be infected.
Students will be asked to write letters to their local MP to push for more funding support for children directly affected by the disease and to develop creative ideas, which will be collated by the campaign's organisers and sent to the Government next year.
Sarah Coe, youth manager at World Vision, said that the agencies want young people to feel that they are taking part in a massive worldwide movement.