Contact a Family is calling on the Children's Minister Margaret Hodge to improve the support and care available to parents expecting a disabled child, after research showed that nearly half of the parents of disabled children surveyed said they had marital problems as a result.
One in 10 of those that took part in the 'No Time For Us' research claimed that the stress caused by bringing up a disabled child led to separation.
More than half said that they had financial difficulties, with the majority linking this to having a disabled child.
The charity says the research shows that more needs to be done to provide respite-care services, in order to give parents a break so they can focus on each other.
Contact a Family is also calling on Hodge to recognise there is a need for more emotional support and counselling, and an improvement to the information available to parents about diagnosis.
"We need to show policy-makers that the lack of good information and support at the point of diagnosis can have a devastating impact on families," said Jill Harrison, director of external affairs at the charity.