The company said it would donate £100,000 plus the proceeds from all ticket sales for its London Winter Concert, which took place in the capital on Tuesday and was expected to be attended by more than 2,500 people.
The concert, held at the Royal Festival Hall, included performances from the classical singers Russell Watson and Carly Paoli.
The Chinese company has attracted controversy in recent years, with some western governments expressing concerns that its technology could enable the Chinese government to spy on them.
The company has denied all such claims.
The NSPCC said it undertook due diligence before agreeing to be a beneficiary of Huawei’s winter concert.
Mike McGrath, head of partnerships at the NSPCC, said in a statement: "The generous donations from Huawei and its winter concert will enable us to be there for children who have nowhere else to turn, particularly as Childline is the only service open to children 24/7 during the festive period."
Victor Zhang, vice-president of Huawei, said: "This is Huawei’s 10th winter concert in London.
"Such a great milestone shows our long-term commitment to the UK and particularly to our partners and customers."
"We know Childline receives a call every 25 seconds from someone in need. Because the NSPCC is such a deserving cause, we will make this additional donation to the charity to support the important work it does."