RNIB's director-general Ian Bruce is to step down at the end of the year after 20 years in the post.
Bruce, the longest-serving boss of a top 50 charity, will leave in December to expand the academic programme for the voluntary sector at Cass Business School at City University, where he is a visiting professor. He will retain his links with RNIB as a vice president of the charity.
"The end of this year will be a good time for me to step down at RNIB," said Bruce. "Last year's financial problems are now behind us and we have a better than break even budget for this year.
"RNIB has just finished two of the most successful years in the past 20 years with the launch our new digital Talking Books service, the move into our new London HQ and services centre and the launch of our mass-membership scheme."
Colin Low, chairman at RNIB, said Bruce had helped the charity to become "one of the country's most successful campaigning and lobbying organisations".