His appointment comes as the magazine, which has a circulation of more than 20,000, relaunches with its first major redesign in 23 years.
Macrae said: "I am delighted to become the first disabled editor of DN, which marks a historic moment for the magazine, and proud to lead a publication that has campaigned so passionately for disabled people's rights for more than two decades."
The redesign will see the magazine's website becoming more news-based and the print magazine changing into a lifestyle, features-based publication. The views of disabled people were sought in shaping the new look. The official relaunch takes place on 25 October. Macrae will speak for the first time as editor at the event.