The Meningitis Trust will benefit from the weekly BBC Radio 4 appeal for the first time on Easter Sunday.
The trust applied to the station a year ago and had its application accepted last September. The three-minute appeal will be delivered by 21-year-old Aaron Phipps, who contracted meningococcal septicaemia at 15 and had to learn to walk with prosthetic limbs after both legs were amputated.
Previous charity appeals on Radio 4 have raised several thousand pounds.
But a spokeswoman for the trust declined to set a total for the Easter appeal because she couldn't account for the "possible knock-on effect of the tsunami and Comic Relief".
Rather than asking for a specific donation, the appeal says that £10 will pay for 1,000 symptoms cards for people to carry in their wallets.
It will be broadcast twice on 27 March and repeated on 31 March.