Cancer and Leukaemia in Childhood has attributed a 23 per cent rise in total income to a more targeted fundraising approach after it raised £8m last year - the most in its 28-year history.
Claudia McVie, director of fundraising and marketing at the charity, said the largest increases came from major events and corporate links with companies such as Dyson, although income from all fundraising streams increased.
Dyson pledged to raise £1m, and started by running an online competition called Colour My Dyson that asked people to design a Dyson vacuum cleaner.
A dinner and ball held at the Natural History Museum raised £200,000.
"A charity of our size can't be too dependant on one income stream, so we raise money from wide-ranging methods," said McVie.
The extra money has enabled CLIC to develop beyond its south-western roots to build strong bases in London and Scotland.