Politicians will have the opportunity to put journalists under fire at Cancer Research UK's annual Turn the Tables fundraising event, which will be held on 17 October at the Savoy Hotel in London.
David Blunkett, the Secretary of State for Work and Pensions, will quiz Piers Morgan, former editor of the Daily Mirror. Conservative MP Malcolm Rifkind will be questioning Jon Snow, the Channel 4 News presenter.
This is the sixth time heavy hitters from each profession have swapped roles for the event. Snow admitted it would be slightly intimidating, but said he was looking forward to experiencing the other side for once.
"I think it's an excellent idea," he said. "It's time the playing field was levelled. Journalists have had it their own way for too long."
Guests will be able to pose questions to Morgan or Snow for a £100 donation to Cancer Research UK.
Since its launch in 2000, Turn the Tables has raised more than £300,000.