Comic Relief launched spin-off campaign Sport Relief 2006 last week following a two-year break. This year's day of fundraising events takes place on 15 July and the charity hopes to improve on the £16m raised in 2004.
One of the main events will be the Sport Relief Mile, which is sponsored by Sainsbury's.
Sport Relief raises funds for projects that tackle poverty in the UK and overseas. "Our target is always to do better than before," said a spokeswoman.
Sport Relief Saturday will feature a five-hour BBC 1 TV programme presented by Davina McCall, Chris Evans and Gary Lineker, as well as live coverage from the 15 runs presented by John Inverdale and Colin Jackson. Other celebrity supporters include chef Jamie Oliver.
Comic Relief set up Sport Relief in partnership with BBC Sport in 2002.
In 2004, the initiative raised more than £16m from the 80,000 people who took part in the run.