Y Care International has partnered with retail chain Safeway for a month-long fundraising campaign to aid the charity's work with street children.
Nearly 350 Safeway stores across England and Wales are set to display collecting tins and posters throughout September.
The international aid charity has previously worked with Safeway to raise funds for emergency aid appeals.
"Together Y Care International and Safeway are addressing one of the continuing emergencies - the presence of so many of the world's poorest children on the streets, where they are even more vulnerable,
said Christopher Beer, director at Y Care International. "With support from Safeway customers, we can do something about it, and rescue many young lives."
Y Care International runs projects for street children in countries including Rwanda, India, Thailand and Colombia. It works with families to tackle the root causes of children leaving home.