The Duke and Duchess of Sussex are to break away from the charity they oversee with the Duke and Duchess of Cambridge to set up their own foundation.
A statement from the Royal Foundation, which was set up in 2009, said a review of the charity had concluded that a new charitable foundation for Harry and Meghan would be established later this year.
The existing charity, which will be renamed the Royal Foundation of the Duke and Duchess of Cambridge, will provide transitional support in setting up the new organisation.
Both couples will continue to work together on projects in the future, including on the foundation’s mental health programme Heads Together, the statement said.
Catherine joined the charity after marrying William in 2011. Meghan became part of it after her wedding to Harry last year.
The statement said the changes were designed to better align the charitable activity of the royals with their new households.
"The Duke and Duchess of Cambridge and the Duke and Duchess of Sussex are incredibly proud of what they have achieved together through the Royal Foundation," the statement said.
"They are especially proud to have established a charity that has had, and will continue to have, significant long-lasting impact, changing lives for the better."
The statement said the Cambridges wanted to focus on causes including mental health and the illegal wildlife trade, as well as setting up new schemes looking at the environment and support for children and families.
Details on what causes the new charity will focus on are expected later in the year.
The Royal Foundation had an income of £7.8m and spending of £9m in 2018, its latest accounts show.