Leeds United's financial crisis has forced the club to cease donations to Cancer Research UK.
The Premiership club, which is more than £80m in debt, was making monthly contributions of up to £5,000 to the charity.
Former Leeds chairman Peter Ridsdale set up the partnership about three years ago. The donations went towards CRUK's £2m appeal to pay for a professor and a new clinical research ward at the city's St James Hospital.
Simon Poole, the charity's programme funding manager, said: "Peter Ridsdale had very personal reasons for supporting the charity. Times change and the new management have had to implement very severe cost-cutting.
"The financial support was great, but the club's directors have helped in ways that stretch far beyond that.
"They helped me network with some wealthy Yorkshire businessmen and I'm confident that we will reach the £2m target by this time next year."