She previously worked as director of marketing and public affairs at the British Museum, before which she was director of corporate communications at the University of Westminster.
Homden said: "It's a privilege to join such a distinguished organisation. I'm looking forward to developing Coram's excellent work supporting society's most vulnerable children and young people."
She succeeds Honor Rhodes, who resigned from the post last August because of a divergence of opinion between her and the charity's governors.
Lucy Bertenshaw and Owen Gibbons have joined WWF-UK as senior campaign officers. Bertenshaw has recently returned from Peru, where she worked on a project to improve the working conditions of the Inca Trail porters. Gibbons previously spent two years in the campaigns team at Amnesty International's International Secretariat.
David Ford is the new chief executive of the National Centre for Young People with Epilepsy. He joins from Shelter, where he was director of services. Ford previously worked as director for the southern region at Leonard Cheshire and as a regional director for deafblind charity Sense.
John Feaver has taken up the role of head of fundraising at children's cricketing charity the Lord's Taverners. He leaves the Lawn Tennis Association after 22 years, vacating the role of director of international sponsorship.
Moira Clarkson has joined the British Lung Foundation as supporter relations manager. She joins from the Royal Hospital for Neuro-disability, where she was donor development manager. Clarkson previously worked in the fundraising teams at the British Deaf Association and the Children's Society.
Cathy Gilman has been promoted to chief executive of Leukaemia Research. Kate White will take up Gilman's previous role of director of fundraising. White was formerly corporate and events manager at the charity. Gilman takes over from retiring chief executive Douglas Osborne.
Emma Sheppard has taken up the newly created post of PR manager at St John Ambulance. She joins the charity from Breakthrough Breast Cancer, where she worked in the campaigns team.
Paula Hackett is the new training and development officer at the Volunteer Development Agency, the organisation for the development of volunteering in Northern Ireland. She joins from Dungannon and South Tyrone Borough Council, where she worked as a training officer.
Vishnee Sauntoo has been appointed campaign manager of the No Smoking Day charity. He previously worked for four and a half years as a press officer for fertility regulator the Human Fertilisation and Embryology Authority.
The Rev Mark Warner has taken up the newly created role of community relations coordinator at the British and International Sailors' Society. Warner leaves 30 years of church-based ministry to take up the position.