It says the position, which will involve lobbying politicians on issues such as fundraising regulation and taxation, reflects its growing interest in policies that can affect the way charities work.
"Our core policy interest is cancer, but this post is a recognition that there is another area of policy that matters and affects us as an organisation," said Catherine Foot, head of policy development at CRUK.
She said her organisation had already started to take a lead in voluntary sector initiatives - for example, last year it set up the Unclaimed Assets Charity Coalition with Guide Dogs.
Foot said CRUK did not intend to rival the umbrella bodies already working in this area. "I hope we'll work really closely with them," she said.
CRUK will start recruitment for the post at the end of March.