David Jones, chairman of Next, is publishing a book about his 23-year struggle with Parkinson's disease in a bid to raise money for his charity, the Cure Parkinson's Trust.
The trust was set up in November and is soon to obtain charity status.
It aims to raise £2.5m over the next five years to fund research into a cure for the degenerative disease.
"The aim is to channel funds via other Parkinson's organisations and to work with them towards a brighter future for all those affected," Jones said.
The royalties from Jones's autobiography Next To Me, published tomorrow, will join the £500,000 raised by the trust's co-founders Sir Richard Nichols, Michael Dicken and Tom Isaacs.
"David's story is good for Parkinson's sufferers - we don't have any Michael J Foxes in this country," said Geraldine Peacock, chair of the Charity Commission and a fellow sufferer.