The NSPCC is to shed 45 jobs but hopes to create 300 new ones over the next seven years.
The shake-up at the children's charity follows the publication of its new strategy for the period from 2009 to 2016.
The strategy, which was announced this week, says the charity's work will focus on seven priority areas. They are: neglect; physical abuse in high-risk families; sexual abuse; children under one; children with disabilities; children from certain black and minority ethnic communities; and looked-after children.
Andrew Flanagan, chief executive of the NSPCC, said nine of the charity's 120 services that did not fit into the new strategy would close. Staff in Cumbria, Kent and Guernsey are among those affected. "If possible, we will absorb them within other roles," said Flanagan.
The strategic review is the first major examination of the charity's work since its Full Stop campaign began in 1999, with a goal to raise £250m and to end child cruelty.
The new strategy anticipates a 15 per cent growth in staff numbers by 2016, which would see the total number of NSPCC employees rise from about 2,000 to 2,300.
Flanagan, who succeeded Dame Mary Marsh in January, said the charity was not "assuming significant increases in fundraising" but would not reveal its predictions for income.
He did, however, say that the charity had recently removed a recruitment freeze and agreed a 1 per cent pay rise for staff in January.
"It's not a hugely generous increase," said Flanagan. "But staff see it as a sign that we're stable and have the confidence to make that kind of increase."
* See next week's Third Sector magazine for an interview with Andrew Flanagan