Tanya Barron, chief executive of the children’s charity Plan International UK, is to retire in June.
Barron, who has worked in international development for most of her career, has been head of the charity since 2013.
A statement from Plan said she had been inspired to join the charity after seeing its Because I Am a Girl campaign, set up to transform girls’ lives through education.
She has overseen growth in the charity’s overall income during her time in post. It rose from £52.9m in 2012/13 to a high of £80.4m two years later, before falling back to £64.3m in 2016/17.
Barron said she had been privileged to work for the charity and that one of her highlights had been seeing its young campaigners work to successfully change marriage laws in Malawi.
She said a highlight of a different kind was when she was caught up in the Nepal earthquake in 2015.
"It was terrifying, but I will never forget being immediately pulled into the local Plan emergency team and working all hours to get shelter and assistance to families left with nothing," she said. "It was Plan in action, at its best".
Professor Sir Ian Diamond, chair of the charity, said: "Tanya’s dedication and passion for gender equality mean she has worked tirelessly over the past six years to establish Plan International UK as a leader in championing children's rights."
Plan said it was in the early stages of the process to recruit Barron’s successor.