The Prince's Trust is set to make up to 21 staff redundant and scale back its volunteer programmes across Wales after losing the bulk of its statutory funding.
The charity says it is "streamlining" operations at The Prince's Trust Cymru after a fall in funding from bodies including Education and Learning in Wales, which is itself facing financial problems.
This will lead to consultation over the 21 jobs and a reduction in the delivery of the The Prince's Trust Team Programme, formerly known as the Volunteers Programme.
A spokesman for The Prince's Trust Cymru said the potential job cuts also reflected a management restructure at the Welsh offices.
"Any changes also reflect our increased emphasis on using local outreach services rather than office-based job roles and a new integrated management structure," he said.
The moves come just months after The Prince's Trust rebranded to modernise its image and attract younger supporters.