The part government-funded charity that works with refugees wants to understand the underlying motivation behind donor response, particularly in the case of long-term donors.
The charity has bought lists of potential donors that match the profile of its long-term donors, as it aims to reach its target of 3,000 new donors a year.
The Refugee Council will distribute material to 80,000 people from the new lists in two mailouts during April.
The campaign, by Whitewater, an agency specialising in the not-for-profit sector, was instigated by the charity's new direct marketing manager Clare Millerchip.
"We have a complex cause to communicate to potential donors and we are keen to investigate new approaches that can help us target our direct marketing more effectively," said Millerchip.