The helpline, for people with relationship problems, is expected to go live in the next 12 to 18 months. It will begin with a pilot service from a call centre based in Doncaster, south Yorkshire.
The charity will begin recruiting for the new posts immediately and is to offer on-the-job training.
Financial backing for the helpline has been provided by regional development agency Yorkshire Forward.
A spokeswoman for the charity emphasised that the service will not just be aimed at couples.
"It's for anyone with relationship issues," she said. "That could be someone worried that their marriage is breaking down, or it could also be a parent who is concerned about arguments within the family."