Its director-general, Mike Aaronson, has also announced he will stand down in September after 17 years at the charity to hand over to someone who will bring "a fresh perspective".
Peter Harlock, chief operating officer at Save the Children, whose president is HRH The Princess Royal, denied the changes were forced by a financial crisis, but said expenditure was being "adjusted". This adjustment had been sparked by "over-optimistic" forecasting of income levels and a drop in reserves caused by the updating of IT, finance and HR systems three years ago.
The restructure will cause 80 to 100 regional specialists to lose their jobs out of the 400 employed at the London headquarters, but up to 20 new roles will be created to provide support to the regional offices on issues such as HIV/Aids.
The charity's seven working regions across the world will be reduced to six, with the previous three African regions being amalgamated into two. Each regional office will have up to seven employees, both expatriate and local staff found through open recruitment. Country offices will remain the same, with the number of staff depending on the situation.
A replacement for Aaronson will be sought in due course.