The national mental health charity Rethink is transferring its services and 75 staff in Wales to Hafal, a new charity for people suffering severe mental illness.
The independent charity has been created in response to Welsh devolution following a consultation process among staff, supporters and service users in which 90 per cent approved the transition.
Hafal, which was launched last week, means 'equal' in Welsh. Chair Peter Davey said: "The status of a Wales-specific organisation will enhance development of services and policy work in Wales and provide a more appropriate policy match with the Wales Assembly Government.
"The changes we are making will, even in the short term, make a real difference to individuals and families who face the challenge of severe mental illness."
Bob Banner, chair of Rethink, said the move would enable campaigns to be targeted specifically towards each country's politicians. "It will enable services and support to be delivered in the most appropriate manner," he added.