Royal Voluntary Service, the older people’s charity, is to make up to 144 of its 1,575 employees redundant in a restructure this summer.
The charity, which posted a deficit of almost £4m in the year ending March 2013, said it was aiming to "streamline its structure".
A spokeswoman for the charity, which had an income of £73.2m last year, said that people working in both the operations and support team services could be affected by the proposals.
"It is not possible to know the actual number of redundancies that will result from this exercise because the proposals, including ways to mitigate redundancies, are currently under consultation with the employee forum at RVS," she said.
"Until that process is complete, we are not in a position to say how many roles will go. We will be doing everything we can to reduce and avoid job losses, and to support our employees at this difficult time."
David McCullough, chief executive of RVS, said the charity recognised that it needed to "scale up our services in the most sustainable way" in order to play a greater role in caring for older people in the community.
"For us, this means reducing our running costs while empowering our volunteers on the front line," he said. "Sadly, these proposals include some job losses at the charity. At the moment we’re discussing our proposals with affected employees and are listening to their views on how we can make the changes."
He said that the charity was committed to ensuring its 35,000 volunteers were well informed and that there was no impact on the care provided to service users, which make up more than 100,000 older people.
RVS is also proposing to strengthen retail management skills in its shops and cafes located in hospitals to increase the financial contribution from these activities.