Ruth Sutherland, chief executive of Samaritans, will leave her role next year, the charity has announced.
Sutherland, who has led the charity since August 2015, will step down in March 2020 to pursue a portfolio career.
The charity has already begun a recruitment process to find Sutherland’s successor.
Before joining Samaritans, Sutherland was chief executive of the relationship support charity Relate from 2012.
Sutherland said in a statement that she had "realised a lifetime ambition" when she joined Samaritans, and cited the impending completion of the charity’s current five-year strategy as a good time to depart.
"After a deeply fulfilling 40-year career in third sector and public sector roles, I believe the time is right for me to start the next chapter pursuing a portfolio career and family life, and I will be stepping down in March 2020," she said.
"I am confident that the future leadership of Samaritans is in safe hands and the next appointed chief executive will continue on our mission to reduce the number of people who die by suicide."
To see the job advertisement from Samaritans, please click here.