Helle Thorning-Schmidt, chief executive of Save the Children International, has announced that she will leave the charity later this year.
The former Danish prime minister, who joined Save the Children International in 2016, is expected to leave "during the coming months" while a successor is sought, according to a statement from the charity, which is based in the UK.
Thorning-Schmidt already serves on a number of boards and has announced that she will join the board of the sustainable energy firm Vestas.
During her time as chief executive, she launched the charity’s long-term strategic plan for reducing childhood deaths, which is called Ambition for Children 2030.
Thorning-Schmidt said: "I step down from my role with a deep sense of pride in the important work we have done to give children a voice, becomiing an organisation that is a better fit for the future and delivers more impact for children."
Pernille Lopez, chair of the Save the Children International, said: "Helle leaves us having made significant and lasting contributions to Save the Children International.
"Lending her talent and voice to the millions of vulnerable children we serve, her impact will continue to be felt for years to come. We are grateful for her service and wish her well in the next chapter of her career."
Save the Children International was set up after the charity decided in 2009 to bring all 30 of the individual Save organisations under one worldwide body.
Jasmine Whitbread was its first chief executive and was succeeded by Thorning-Schmidt.