Scope has hired its first regional fundraising team, saying it needs to get closer to local services and better understand the needs of the north-west's 375,000 disabled people.
The charity has added two fundraisers to its office in north Manchester.
Their remit is to raise £3m over three years, half of which will be ploughed into the maintenance of existing grass-roots services.
Scope regional appeals manager Cathy Elliot said the north-west office would regularly communicate with its service providers across the region.
She has enlisted the support of CBI director general Digby Jones, who will be advising businesses on the spending power of disabled people.
"They spend about £80bn a year on goods and services," he said.