A YoungMinds statement said Barbara Herts will leave the charity this month “to pursue new public policy challenges for children and young people”. Herts declined to confirm what her next career move would be.
Sarah Brennan, who has been working as interim deputy chief executive at the charity since the summer, will take over as acting chief executive while the hunt for a replacement begins.
Mike Shooter, chair of YoungMinds, said the organisation would be conducting “wide and thorough search for a successor”.
“I would like to thank Barbara for championing the mental health of children and young people everywhere,” he added.
Herts said she felt privileged to have led the charity through an exciting period of change.