Sport Relief will for the first time allow the public to raise money through gaming.
The Game Raising campaign, which was launched yesterday, will feature participants creating and playing games that can be viewed on the live-streaming channels Twitch, Facebook Live, YouTube and Mixer.
Comic Relief, the parent charity, says it is the first time gaming has ever been used for its fundraising.
Any fundraiser who wants to set up their own game needs to pick a gaming activity and set a Game Raising donation target using a fundraising page. They can do this alone or in a group. The game can take place at home, at work, at university or at a local park.
Participants may even donate to change the outcome of the challenge. For example, if a fundraiser reaches £100, they could ask donors to donate to change the challenge when they reach £200.
Activities suggested by Sport Relief, which will take place on 13 March, include gaming-themed bake sales, cosplay competitions or pay-to-play board game tournaments.
A donation button on the Sport Relief website will allow those who would like to watch participants on live streams to donate to the charity.
Other events in this year’s Sport Relief include The Heat Is On, which consists of celebrity gamers running, biking and skiing 100 miles through the Namib Desert in Namibia, starting from south of the Kuiseb River to a shipwreck on the Skeleton Coast.
Celebrities taking part include radio presenter Nick Grimshaw, The Saturdays singer Frankie Bridge and the TV personality Robert Rinder.
A Beat Beethoven challenge will also take place involving fundraisers running a 5km route around the BBC's MediaCityUK base in Manchester before the BBC Philharmonic finishes playing Beethoven’s 32-minute long Fifth Symphony.
Liz Hadley, head of new ventures at Comic Relief, said: “We’re really excited about this new initiative for Sport Relief. Our Game Raising campaign is our first step in offering a new way to fundraise for the charity, whether that’s e-sports, board gaming, card games or whichever way you play.
“We can’t wait to see everyone raise their game to support Sport Relief.”