TK Maxx has raised £32.5m for Cancer Research UK over the past 15 years, the organisations have announced.
To mark the 15th anniversary, the retailer has pledged to fund, through customer donations and employee fundraising, a new CRUK brain tumour centre focused on children and young people
The partnership has raised money through donations of cash and stock, plus employee fundraising and the sale of ribbon pin badges.
Campaigns include Give Up Clothes for Good, in which customers are encouraged to donate old clothes to CRUK’s shops through TK Maxx stores.
Money from the partnership has been used specifically to fund CRUK’s work on cancers that affect children and young people.
Jo Murphy, assistant vice president of corporate responsibility at TK Maxx, said the company was "incredibly grateful" to its employees and customers.
"We hope our support will go some way towards improving the outcomes of children and young people affected by cancer," she said.
Morag Stocks, head of corporate partnerships at CRUK, said the charity was "overwhelmed by the incredible amount" that TK Maxx staff and customers had raised.
"The support of donors and partners such as TK Maxx plays a huge role in helping us fund more research to ensure more children and young people survive cancer with a good quality of life."