The Neurofibromatosis Association has been inundated with calls after two TV programmes about the condition were screened in one week.
BBC1's When Your Face Doesn't Fit showed how three people with neurofibromatosis are ostracised in their communities.
The charity received 25 callers in the first morning after the show from people who had been referred to it by the BBC helpline.
Mark Stevens, the association's general secretary, said: "We normally take about two unsolicited calls for help a day."
The condition is a disorder of the nerves which can lead to facial disfigurements.
A second programme about the condition shown on Channel 4 on Monday was expected to maintain the momentum of calls to the charity.